ParkinsonCanadaV1, Main, Exploration, bibRecord, 000F54

Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease

Identifieur interne : 000F54 ( Main/Exploration ); précédent : 000F53; suivant : 000F55

Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease

Auteurs : Ji Hyun Ko [Canada] ; Francesca Antonelli [Canada] ; Oury Monchi [Canada] ; Nicola Ray [Canada] ; Pablo Rusjan [Canada] ; Sylvain Houle [Canada] ; Anthony E. Lang [Canada] ; Leigh Christopher [Canada] ; Antonio P. Strafella [Canada]

Source :

Human Brain Mapping [ 1065-9471 ] ; 2013-07.

RBID : ISTEX:D116DEFCFCAC28FDB1475102FA836C3FEDF2BE7E

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Brain Mapping, Carbon Isotopes (pharmacokinetics), Cognition Disorders (etiology), Dopamine Antagonists (pharmacokinetics), Executive Function (physiology), FLB‐457, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (diagnostic imaging), Parkinson Disease (pathology), Positron-Emission Tomography, Prefrontal Cortex (diagnostic imaging), Prefrontal Cortex (drug effects), Prefrontal Cortex (metabolism), Psychiatric Status Rating Scales, Pyrrolidines (pharmacokinetics), Receptors, Dopamine (metabolism), Salicylamides (pharmacokinetics), Statistics as Topic, Statistics, Nonparametric, cognition, mesocortical dopamine, positron emission tomography, set‐shifting.
MESH :
- chemical , metabolism : Receptors, Dopamine.
- chemical , pharmacokinetics : Carbon Isotopes, Dopamine Antagonists, Pyrrolidines, Salicylamides.
- complications : Parkinson Disease.
- diagnostic imaging : Parkinson Disease, Prefrontal Cortex.
- drug effects : Prefrontal Cortex.
- etiology : Cognition Disorders.
- metabolism : Prefrontal Cortex.
- pathology : Parkinson Disease.
- physiology : Executive Function.
- Aged, Aged, 80 and over, Brain Mapping, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Psychiatric Status Rating Scales, Statistics as Topic, Statistics, Nonparametric.

Abstract

The main pattern of cognitive impairments seen in early to moderate stages of Parkinson's disease (PD) includes deficits of executive functions. These nonmotor complications have a significant impact on the quality of life and day‐to‐day activities of PD patients and are not effectively managed by current therapies, a problem which is almost certainly due to the fact that the disease extends beyond the nigrostriatal system. To investigate the role of extrastriatal dopamine in executive function in PD, PD patients and a control group were studied with positron‐emission‐tomography using a high‐affinity dopamine D2/D3 receptor tracer, [11C]FLB‐457. All participants were scanned twice while performing an executive task and a control task. Patients were off medication for at least 12 h. The imaging analysis revealed that parkinsonian patients had lower [11C]FLB‐457 binding than control group independently of task conditions across different brain regions. Cognitive assessment measures were positively correlated with [11C]FLB‐457 binding in the bilateral dorsolateral prefrontal cortex and anterior cingulate cortex only in control group, but not in PD patients. Within the control group, during the executive task (as compared to control task), there was evidence of reduced [11C]FLB‐457 binding (indicative of increased dopamine release) in the right orbitofrontal cortex. In contrast, PD patients did not show any reduction in binding during the executive task (as compared with control task). These findings suggest that PD patients present significant abnormalities in extrastriatal dopamine associated with executive processing. These observations provide important insights on the pathophysiology of cognitive dysfunction in PD. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.

Url:

DOI: 10.1002/hbm.22006

Affiliations:

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<front><div type="abstract" xml:lang="en">The main pattern of cognitive impairments seen in early to moderate stages of Parkinson's disease (PD) includes deficits of executive functions. These nonmotor complications have a significant impact on the quality of life and day‐to‐day activities of PD patients and are not effectively managed by current therapies, a problem which is almost certainly due to the fact that the disease extends beyond the nigrostriatal system. To investigate the role of extrastriatal dopamine in executive function in PD, PD patients and a control group were studied with positron‐emission‐tomography using a high‐affinity dopamine D2/D3 receptor tracer, [11C]FLB‐457. All participants were scanned twice while performing an executive task and a control task. Patients were off medication for at least 12 h. The imaging analysis revealed that parkinsonian patients had lower [11C]FLB‐457 binding than control group independently of task conditions across different brain regions. Cognitive assessment measures were positively correlated with [11C]FLB‐457 binding in the bilateral dorsolateral prefrontal cortex and anterior cingulate cortex only in control group, but not in PD patients. Within the control group, during the executive task (as compared to control task), there was evidence of reduced [11C]FLB‐457 binding (indicative of increased dopamine release) in the right orbitofrontal cortex. In contrast, PD patients did not show any reduction in binding during the executive task (as compared with control task). These findings suggest that PD patients present significant abnormalities in extrastriatal dopamine associated with executive processing. These observations provide important insights on the pathophysiology of cognitive dysfunction in PD. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease

Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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	La maladie de Parkinson au Canada (serveur d'exploration)
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